Speckle-type POZ protein (SPOP) is a gene that encodes a protein that regulates the transcriptional repression carried out by death-associated protein 6 (DAXX). Missense mutations, nonsense mutations, silent mutations, frameshift insertions, and in-frame deletions are observed in cancers such as endometrial cancer, meningeal cancer, and prostate cancer.
Modified: July 1, 2015
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