Speckle-type POZ protein (SPOP) is a gene that encodes a protein that regulates the transcriptional repression carried out by death-associated protein 6 (DAXX). Missense mutations, nonsense mutations, silent mutations, frameshift insertions, and in-frame deletions are observed in cancers such as endometrial cancer, meningeal cancer, and prostate cancer.
SPOP is altered in 1.83% of all cancers with prostate adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, invasive breast carcinoma, and lung adenocarcinoma having the greatest prevalence of alterations .
The most common alterations in SPOP are SPOP Mutation (1.29%), SPOP Amplification (0.58%), SPOP F133L (0.13%), SPOP F133V (0.12%), and SPOP F102C (0.07%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.