Biomarkers /
SQSTM1
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Associated Diseases
Overview
SQSTM1 is altered in 0.40% of all cancers with lung adenocarcinoma, breast invasive ductal carcinoma, colon adenocarcinoma, bladder urothelial carcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].
The most common alterations in SQSTM1 are SQSTM1-FGFR1 Fusion (0.24%), SQSTM1-ALK Fusion (0.05%), SQSTM1-NTRK1 Fusion (0.08%), SQSTM1-NTRK3 Fusion (0.03%), and SQSTM1-NTRK2 Fusion (0.07%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.