Location [1]
Protein [2]
Protein SSXT
Synonyms [1]

Synovial sarcoma translocation, chromosome 18 (SS18) is a gene that encodes a protein that shows experimental evidence of functions on the transcriptional level. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

SS18 is altered in 0.23% of all cancers with colon adenocarcinoma having the greatest prevalence of alterations [3].

SS18 GENIE Cases - Top Diseases

The most common alterations in SS18 are SS18 Loss (0.04%) and SS18 Amplification (0.04%) [3].

SS18 GENIE Cases - Top Alterations

Significance of SS18 in Diseases

Malignant Solid Tumor +

Synovial Sarcoma +

Epithelioid Sarcoma +

Rhabdoid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.