Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
Xp11.23
Protein [2]
Protein SSX1
Synonyms [1]
CT5.1, SSRC

Synovial sarcoma, X breakpoint 1 (SSX1) is a gene that encodes a protein that functions as a transcriptional repressor. The protein also elicits humoral and cellular immune responses in cancer patients. Fusions, missense mutations, nonsense mutations, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer

Significance of SSX1 in Diseases

Malignant Solid Tumor +

Synovial Sarcoma +

Epithelioid Sarcoma +

Rhabdoid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.