Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
2q32.2
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 1-alpha/beta
Synonyms [1]
IMD31A, CANDF7, IMD31C, ISGF-3, IMD31B, STAT91

Signal transducer and activator of transcription 1 (STAT1) is a gene that encodes a member of the STAT protein family that functions as a transcription activator when translocated to the nucleus of a cell. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame insertions are observed in cancers such as cervical cancer, endometrial cancer, and stomach cancer.

Significance of STAT1 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.