Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
12q13.3
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 2
Synonyms [1]
STAT113, IMD44, P113, ISGF-3

Signal transducer and activator of transcription 2 (STAT2) is a gene that encodes a member of the STAT protein family that functions as a transcription activator when translocated to the nucleus of a cell. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as cervical cancer, endometrial cancer, and intestinal cancer.

Significance of STAT2 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.