Associated Genetic Biomarkers
Associated Diseases
Associated Pathways


Location [1]
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 4
Synonyms [1]

Signal transducer and activator of transcription 4 (STAT4) is a gene that encodes a transcription factor protein that mediates responses to IL12 in lymphocytes and regulates the differentiation of helper T-cells. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

STAT4 is altered in 1.72% of all cancers with cutaneous melanoma, colon adenocarcinoma, melanoma, conventional glioblastoma multiforme, and lung adenocarcinoma having the greatest prevalence of alterations [3].

STAT4 GENIE Cases - Top Diseases

The most common alterations in STAT4 are STAT4 Mutation (1.59%), STAT4 Amplification (0.20%), STAT4 R400* (0.20%), STAT4 R705Q (0.09%), and STAT4 D256N (0.14%) [3].

STAT4 GENIE Cases - Top Alterations

Significance of STAT4 in Diseases

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.