Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
17q21.2
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 5A
Synonyms [1]
MGF, STAT5

Signal transducer and activator of transcription 5A (STAT5A) is a gene that encodes a protein that functions as a transcription activator. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

STAT5A is altered in 0.66% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, prostate adenocarcinoma, and high grade ovarian serous adenocarcinoma having the greatest prevalence of alterations [3].

STAT5A GENIE Cases - Top Diseases

The most common alterations in STAT5A are STAT5A Mutation (0.26%), STAT5A Amplification (0.06%), STAT5A Loss (0.05%), STAT5A Q368Rfs*2 (0.01%), and STAT5A R649W (0.01%) [3].

STAT5A GENIE Cases - Top Alterations

Significance of STAT5A in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.