Associated Genetic Biomarkers
Associated Diseases
Associated Pathways

Overview

Location [1]
12q13.3
Pathway
JAK/STAT signaling
Protein [2]
Signal transducer and activator of transcription 6
Synonyms [1]
STAT6C, IL-4-STAT, STAT6B, D12S1644

Signal transducer and activator of transcription 6, interleukin-4 induced (STAT6) is a gene that encodes a protein that functions as a transcription activator. The protein is specifically important for in IL4 mediated biological responses. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

STAT6 is altered in 1.72% of all cancers with lung adenocarcinoma, solitary fibrous tumor, endometrial endometrioid adenocarcinoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

STAT6 GENIE Cases - Top Diseases

The most common alterations in STAT6 are STAT6 Mutation (0.64%), STAT6 Amplification (0.07%), STAT6 L406V (0.01%), STAT6 Q104K (0.01%), and STAT6 G819A (0.01%) [3].

STAT6 GENIE Cases - Top Alterations

Significance of STAT6 in Diseases

Malignant Solid Tumor +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.