Overview

Location [1]
10q24.32
Pathway
Hedgehog signaling
Protein [2]
Suppressor of fused homolog
Synonyms [1]
SUFUH, PRO1280, JBTS32, SUFUXL

Suppressor of fused homolog (SUFU) is a gene that encodes a protein that functions as a negative regulator of the hedgehog signaling pathway. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as pleural cancer, skin cancer, and stomach cancer.

SUFU is altered in 0.76% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, prostate adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

SUFU GENIE Cases - Top Diseases

The most common alterations in SUFU are SUFU Mutation (0.75%), SUFU Loss (0.12%), SUFU A25Gfs*23 (0.03%), SUFU Amplification (0.02%), and SUFU R123C (0.02%) [3].

SUFU GENIE Cases - Top Alterations

Significance of SUFU in Diseases

Medulloblastoma +

Medulloblastoma, Non-WNT/Non-SHH +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Desmoplastic/Nodular Medulloblastoma +

Large Cell/Anaplastic Medulloblastoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Malignant Glioma +

Diffuse Glioma +

Glioblastoma +

Anaplastic Astrocytoma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Atypical Teratoid/Rhabdoid Tumor +

Diffuse Midline Glioma, H3 K27M-Mutant +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma +

Ependymoma, RELA Fusion-Positive +

High-Grade Glioma, NOS +

Intracranial Primitive Neuroectodermal Neoplasm +

Pineoblastoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.