Location [1]
Protein [2]
Transforming acidic coiled-coil-containing protein 3
Synonyms [1]
ERIC1, Tacc4, maskin, ERIC-1

TACC3 is altered in 0.26% of all cancers with bladder urothelial carcinoma, conventional glioblastoma multiforme, lung adenocarcinoma, glioblastoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

TACC3 GENIE Cases - Top Diseases

The most common alteration in TACC3 is TACC3-FGFR3 Fusion (0.11%) [3].

TACC3 GENIE Cases - Top Alterations

Biomarker-Directed Therapies

Significance of TACC3 in Diseases

Bladder Carcinoma +

Urothelial Carcinoma +

Glioma +

Malignant Glioma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.