Overview

Location [1]
1p33
Protein [2]
T-cell acute lymphocytic leukemia protein 1
Synonyms [1]
TCL5, tal-1, SCL, bHLHa17

T-cell acute lymphocytic leukemia 1 (TAL1) is a gene that encodes a protein that functions in the development in hemopoietic malignancies. The protein acts as a positive regulator of erythroid differentiation and may be involved in hemopoietic differentiation. Fusions, missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

TAL1 is altered in 1.23% of all cancers with lung adenocarcinoma, colon adenocarcinoma, melanoma, endometrial endometrioid adenocarcinoma, and pancreatic adenocarcinoma having the greatest prevalence of alterations [3].

TAL1 GENIE Cases - Top Diseases

The most common alterations in TAL1 are TAL1 G269S (0.09%), TAL1 A104L (0.06%), TAL1 E8A (1.87%), TAL1 R331W (0.04%), and TAL1 V88M (0.06%) [3].

TAL1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.