Overview

Location [1]
10q25.2-q25.3
Protein [2]
Transcription factor 7-like 2
Synonyms [1]
TCF-4, TCF4

Transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2) is a gene that encodes a transcription factor protein that is involved in the WNT signaling pathway. The protein functions in blood glucose homeostasis. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as fallopian tube cancer, intestinal cancer, and stomach cancer.

TCF7L2 is altered in 1.99% of all cancers with colon adenocarcinoma, rectal adenocarcinoma, colorectal adenocarcinoma, lung adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

TCF7L2 GENIE Cases - Top Diseases

The most common alterations in TCF7L2 are TCF7L2 R488C (0.09%), TCF7L2 Loss (0.09%), TCF7L2 Amplification (0.07%), TCF7L2 X334_splice (0.04%), and TCF7L2 R420W (0.03%) [3].

TCF7L2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.