Associated Genetic Biomarkers
T-cell leukemia/lymphoma 1A (TCL1A; also known as TCL1) is a gene that encodes a protein that functions as a coactivator of AKT - a cell survival kinase. The protein is also important for the development of mature T cell leukemia. Fusions, missense, nonsense, and silent mutations are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.
TCL1A is altered in 0.29% of all cancers with lung adenocarcinoma, esophageal adenocarcinoma, glioblastoma, and non-small cell lung carcinoma having the greatest prevalence of alterations .
The most common alterations in TCL1A are TCL1A Mutation (0.29%), TCL1A A2S (0.08%), TCL1A G102C (0.26%), TCL1A R48Q (0.22%), and TCL1A V25M (0.08%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.