Overview

Location [1]
9p21.2
Protein [2]
Angiopoietin-1 receptor
Synonyms [1]
TIE-2, TIE2, VMCM1, GLC3E, VMCM, CD202B

TEK is altered in 1.83% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, cutaneous melanoma, conventional glioblastoma multiforme, and colon adenocarcinoma having the greatest prevalence of alterations [3].

TEK GENIE Cases - Top Diseases

The most common alterations in TEK are TEK Mutation (0.37%), TEK Loss (0.28%), TEK Amplification (0.05%), TEK P417Lfs*10 (0.01%), and TEK R535C (0.01%) [3].

TEK GENIE Cases - Top Alterations

Significance of TEK in Diseases

Urothelial Carcinoma +

Pancreatic Carcinoma +

Malignant Solid Tumor +

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.