Overview

Location [1]
3q26.2
Synonyms [1]
DKCA1, TRC3, SCARNA19, hTR, TR, PFBMFT2

Telomerase RNA component (TERC) is a gene that encodes a non-coding RNA that serves as a template for the telomere repeat TTAGGG. Amplification is observed in cancers such as squamous cell lung cancer, ovarian cancer, and esophageal cancer.

TERC is altered in 0.42% of all cancers with squamous cell lung carcinoma, high grade ovarian serous adenocarcinoma, anal squamous cell carcinoma, breast invasive ductal carcinoma, and esophageal adenocarcinoma having the greatest prevalence of alterations [3].

TERC GENIE Cases - Top Diseases

The most common alterations in TERC are TERC Amplification (0.44%) and TERC Loss (0.21%) [3].

TERC GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.