Biomarkers /
TNFAIP3
Overview
Tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) is a gene that encodes a protein that functions as a zinc finger protein and ubiquitin-editing enzyme. The protein inhibits NF-kappa B activation and TNF-mediated apoptotic death. Missense mutations, nonsense mutations, silent mutations, whole gene deletions, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as hematopoietic and lymphoid cancers, intestinal cancer, and stomach cancer.
Clinical Trials
Significance of TNFAIP3 in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.