Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
17q21.2
Protein [2]
DNA topoisomerase 2-alpha
Synonyms [1]
TP2A, TOP2

Topoisomerase (DNA) II alpha (TOP2A) is a gene that encodes a protein that controls and alters topologic states of DNA during transcription. Missense mutations, synonymous mutations, frameshift deletions, nonsense mutations, and frameshift insertions are observed in cancers such as colon cancer, skin cancer, and endometrial cancer.

TOP2A is altered in 0.35% of all cancers.

The most common alteration in TOP2A is TOP2A Amplification (0.02%) [3].

TOP2A GENIE Cases - Top Alterations

Significance of TOP2A in Diseases

Breast Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.