Biomarkers /

TP63

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Associated Genetic Biomarkers
Associated Diseases

Overview

Location [1]
3q28
Synonyms [1]
LMS, AIS, p73H, TP53L, B(p51B), OFC8, p40, SHFM4, TP73L, NBP, p51, EEC3, TP53CP, RHS, p63, B(p51A), p53CP, p73L, KET

Tumor protein p63 (TP63) is a gene that encodes a transcription factor protein that functions in the development and maintenance of stratified epithelial tissues. Fusions, missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.