Location [1]
Protein [2]
Tumor protein 63
Synonyms [1]
SHFM4, p51, EEC3, NBP, TP73L, B(p51A), p73H, AIS, LMS, p73L, p53CP, B(p51B), p63, p40, RHS, OFC8, TP53L, KET, TP53CP

Tumor protein p63 (TP63) is a gene that encodes a transcription factor protein that functions in the development and maintenance of stratified epithelial tissues. Fusions, missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

TP63 is altered in 2.12% of all cancers with cutaneous melanoma, lung adenocarcinoma, squamous cell lung carcinoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

TP63 GENIE Cases - Top Diseases

The most common alterations in TP63 are TP63 Mutation (1.52%), TP63 Amplification (0.54%), TP63 Loss (0.06%), TP63 E609K (0.06%), and TP63 R594* (0.05%) [3].

TP63 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.