Associated Genetic Biomarkers
Tumor protein p63 (TP63) is a gene that encodes a transcription factor protein that functions in the development and maintenance of stratified epithelial tissues. Fusions, missense, nonsense, and silent mutations are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
TP63 is altered in 2.12% of all cancers with cutaneous melanoma, lung adenocarcinoma, squamous cell lung carcinoma, colon adenocarcinoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in TP63 are TP63 Mutation (1.52%), TP63 Amplification (0.54%), TP63 Loss (0.06%), TP63 E609K (0.06%), and TP63 R594* (0.05%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.