Location [1]
Protein [2]
TNF receptor-associated factor 2
Synonyms [1]
TRAP3, MGC:45012, RNF117, TRAP

TNF receptor-associated factor 2 (TRAF2) is a gene that encodes a protein that functions in mediating TNF signal transduction by interacting with TNF receptors. The protein is also important for TNF-alpha mediated activation of NF-kappaB and MAPK8/JNK. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as eye cancer, intestinal cancer, and lung cancer.

TRAF2 is altered in 0.81% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

TRAF2 GENIE Cases - Top Diseases

The most common alterations in TRAF2 are TRAF2 Amplification (0.11%), TRAF2 Loss (0.08%), TRAF2 E236K (0.01%), TRAF2 A220T (0.01%), and TRAF2 A375T (0.01%) [3].

TRAF2 GENIE Cases - Top Alterations


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.