TNF receptor-associated factor 2 (TRAF2) is a gene that encodes a protein that functions in mediating TNF signal transduction by interacting with TNF receptors. The protein is also important for TNF-alpha mediated activation of NF-kappaB and MAPK8/JNK. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as eye cancer, intestinal cancer, and lung cancer.
TRAF2 is altered in 0.81% of all cancers with colon adenocarcinoma, lung adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations .
The most common alterations in TRAF2 are TRAF2 Amplification (0.11%), TRAF2 Loss (0.08%), TRAF2 E236K (0.01%), TRAF2 A220T (0.01%), and TRAF2 A375T (0.01%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.