Overview

Location [1]
14q32.32
Protein [2]
TNF receptor-associated factor 3
Synonyms [1]
RNF118, CAP1, IIAE5, CAP-1, LAP1, CD40bp, CRAF1

TNF receptor-associated factor 3 (TRAF3) is a gene that encodes a protein that functions in mediating TNF signal transduction by interacting with TNF receptors. The protein is also important for signal transduction of CD40, the activation of NF-kappaB, and cell death initiated by LTbeta ligation. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

TRAF3 is altered in 0.97% of all cancers with colon adenocarcinoma, melanoma, lung adenocarcinoma, conventional glioblastoma multiforme, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

TRAF3 GENIE Cases - Top Diseases

The most common alterations in TRAF3 are TRAF3 Mutation (1.00%), TRAF3 Loss (0.14%), TRAF3 V367M (0.08%), TRAF3 Amplification (0.05%), and TRAF3 Y116C (0.04%) [3].

TRAF3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.