Tripartite motif containing 24 (TRIM24) is a gene that encodes a protein that function in meditating transcriptional control via the interaction with specific regions of nuclear receptors. These receptors include estrogen, retinoic acid, and vitamin D3 receptors. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as biliary tract cancer, intestinal cancer, and skin cancer.
TRIM24 is altered in 0.26% of all cancers with breast invasive ductal carcinoma, lung adenocarcinoma, colon adenocarcinoma, thyroid gland papillary carcinoma, and melanoma having the greatest prevalence of alterations .
The most common alterations in TRIM24 are TRIM24-FGFR1 Fusion (0.22%), TRIM24-BRAF Fusion (0.07%), TRIM24-RET Fusion (0.05%), TRIM24-NTRK2 Fusion (0.04%), and TRIM24 Q266H (0.43%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.