Biomarkers /
VEGFA
Overview
Vascular endothelial growth factor A (VEGFA) is a gene that encodes a member of the PDGF/VEGF growth factor family. The protein functions as a glycosylated mitogen and acts on endothelial cells to increase vascular permeability, angiogenesis, vasculogenesis, endothelial cell growth, and cell migration. The protein also inhibits apoptosis. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.
Clinical Trials
Significance of VEGFA in Diseases
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.