Overview

Location [1]
6p21.1
Protein [2]
Vascular endothelial growth factor A
Synonyms [1]
MVCD1, VEGF, VPF

Vascular endothelial growth factor A (VEGFA) is a gene that encodes a member of the PDGF/VEGF growth factor family. The protein functions as a glycosylated mitogen and acts on endothelial cells to increase vascular permeability, angiogenesis, vasculogenesis, endothelial cell growth, and cell migration. The protein also inhibits apoptosis. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as endometrial cancer, intestinal cancer, and skin cancer.

VEGFA is altered in 1.11% of all cancers with colon adenocarcinoma, lung adenocarcinoma, breast invasive ductal carcinoma, esophageal adenocarcinoma, and osteosarcoma having the greatest prevalence of alterations [3].

VEGFA GENIE Cases - Top Diseases

The most common alterations in VEGFA are VEGFA Amplification (0.75%), VEGFA Mutation (0.38%), VEGFA Fusion (0.03%), VEGFA Loss (0.02%), and VEGFA R145* (0.01%) [3].

VEGFA GENIE Cases - Top Alterations

Significance of VEGFA in Diseases

Non-Small Cell Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Nasopharyngeal Carcinoma +

Malignant Laryngeal Neoplasm +

Gastric Carcinoma +

Hepatobiliary Neoplasm +

Malignant Hepatobiliary Neoplasm +

Small Cell Lung Carcinoma +

Urothelial Carcinoma +

Malignant Salivary Gland Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Solid Tumor +

Pancreatic Carcinoma +

Oropharyngeal Carcinoma +

Breast Carcinoma +

Gastrointestinal Stromal Tumor +

Nasal Cavity And Paranasal Sinus Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.