Overview

Location [1]
11q13.1
Protein [2]
Vascular endothelial growth factor B
Synonyms [1]
VEGFL, VRF

VEGFB is altered in 0.52% of all cancers with adenosquamous lung carcinoma and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

VEGFB GENIE Cases - Top Diseases

The most common alterations in VEGFB are VEGFB Mutation (0.52%), VEGFB K129fs (0.26%), and VEGFB P147S (0.26%) [3].

VEGFB GENIE Cases - Top Alterations

Significance of VEGFB in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Esophageal Carcinoma +

Gastric Carcinoma +

Gastrointestinal Stromal Tumor +

Hepatobiliary Neoplasm +

Lip And Oral Cavity Carcinoma +

Malignant Hepatobiliary Neoplasm +

Malignant Laryngeal Neoplasm +

Malignant Salivary Gland Neoplasm +

Nasal Cavity And Paranasal Sinus Carcinoma +

Nasopharyngeal Carcinoma +

Oropharyngeal Carcinoma +

Pancreatic Carcinoma +

Small Cell Lung Carcinoma +

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.