Overview

Location [1]
6q21
Pathway
Beta-Catenin/WNT signaling
Protein [2]
WNT1-inducible-signaling pathway protein 3
Synonyms [1]
CCN6, WISP-3, LIBC, PPAC, PPD

WNT1 inducible signaling pathway protein 3 (WISP3) is a gene that encodes a protein that regulates an array of developmental processes. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions and insertions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer.

WISP3 is altered in 0.19% of all cancers with conventional glioblastoma multiforme, melanoma, breast invasive ductal carcinoma, colon adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].

WISP3 GENIE Cases - Top Diseases

The most common alterations in WISP3 are WISP3 Mutation (0.58%), WISP3 Amplification (0.40%), WISP3 R339I (0.13%), WISP3 W205* (0.09%), and WISP3 A119T (0.09%) [3].

WISP3 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.