Overview

Location [1]
12q13.12
Pathway
Beta-Catenin/WNT signaling
Protein [2]
Proto-oncogene Wnt-1
Synonyms [1]
BMND16, INT1, OI15

Wingless-type MMTV integration site family, member 1 (WNT1) is a gene that encodes secreted signaling proteins that function in oncogenesis, regulation of cell fate, and patterning during embryogenesis. Missense mutations, silent mutations, and frameshift deletions are observed in cancers such as breast cancer, intestinal cancer, and stomach cancer.

Significance of WNT1 in Diseases

Esophageal Squamous Cell Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Breast Carcinoma +

Cervical Squamous Cell Carcinoma +

Colorectal Carcinoma +

Esophageal Adenocarcinoma +

Gastric Adenocarcinoma +

Gastric Squamous Cell Carcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Malignant Solid Tumor +

Melanoma +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Squamous Cell Lung Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.