Location [1]
Protein [2]
Werner syndrome ATP-dependent helicase
Synonyms [1]

Werner syndrome, RecQ helicase-like (WRN) is a gene that encodes a protein that functions as a DNA helicase. Missense mutations, silent mutations, nonsense mutations, in-frame deletions, and frameshift deletions are observed in cancers such as peritoneal cancer, colon cancer, and stomach cancer.

WRN is altered in 3.21% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, melanoma, and breast invasive ductal carcinoma having the greatest prevalence of alterations [3].

WRN GENIE Cases - Top Diseases

The most common alterations in WRN are WRN Mutation (2.86%), WRN Loss (0.30%), WRN S1128fs (0.09%), WRN T172P (0.06%), and WRN Amplification (0.04%) [3].

WRN GENIE Cases - Top Alterations

Significance of WRN in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Breast Carcinoma +

Small Cell Lung Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.