Overview

Location [1]
8p12
Protein [2]
Werner syndrome ATP-dependent helicase
Synonyms [1]
RECQL2, RECQL3, RECQ3

Werner syndrome, RecQ helicase-like (WRN) is a gene that encodes a protein that functions as a DNA helicase. Missense mutations, silent mutations, nonsense mutations, in-frame deletions, and frameshift deletions are observed in cancers such as peritoneal cancer, colon cancer, and stomach cancer.

WRN is altered in 2.94% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, breast invasive ductal carcinoma, and rectal adenocarcinoma having the greatest prevalence of alterations [3].

WRN GENIE Cases - Top Diseases

The most common alterations in WRN are WRN Mutation (1.28%), WRN Loss (0.10%), WRN S1128Vfs*34 (0.03%), WRN T172P (0.02%), and WRN T9A (0.02%) [3].

WRN GENIE Cases - Top Alterations

Significance of WRN in Diseases

Malignant Solid Tumor +

Urothelial Carcinoma +

Breast Carcinoma +

Cholangiocarcinoma +

Clear Cell Renal Cell Carcinoma +

Mesothelioma +

Small Cell Lung Carcinoma +

Uveal Melanoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.