Location [1]
Protein [2]
DNA repair protein XRCC2
Synonyms [1]

X-ray repair complementing defective repair in Chinese hamster cells 2 (XRCC2) is a gene that encodes a protein that is involved in maintenance of chromosome stability and DNA damage repair. Missense mutations, silent mutations, frameshift deletions, and frameshift insertions are observed in cancers such as testicular cancer, colon cancer, and stomach cancer.

XRCC2 is altered in 0.62% of all cancers with lung adenocarcinoma, colon adenocarcinoma, endometrial endometrioid adenocarcinoma, cutaneous melanoma, and prostate adenocarcinoma having the greatest prevalence of alterations [3].

XRCC2 GENIE Cases - Top Diseases

The most common alterations in XRCC2 are XRCC2 Mutation (0.36%), XRCC2 Amplification (0.10%), XRCC2 Loss (0.05%), XRCC2 R159H (0.02%), and XRCC2 H40R (0.01%) [3].

XRCC2 GENIE Cases - Top Alterations

Significance of XRCC2 in Diseases

Urothelial Carcinoma +

Malignant Solid Tumor +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.