Overview

Location [1]
14q32.33
Protein [2]
DNA repair protein XRCC3
Synonyms [1]
CMM6

XRCC3 is altered in 0.81% of all cancers with colon adenocarcinoma, endometrial endometrioid adenocarcinoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

XRCC3 GENIE Cases - Top Diseases

The most common alterations in XRCC3 are XRCC3 Mutation (0.15%), XRCC3 T52M (0.01%), XRCC3 Amplification (0.00%), XRCC3 E182K (0.00%), and XRCC3 G271R (0.00%) [3].

XRCC3 GENIE Cases - Top Alterations

Significance of XRCC3 in Diseases

Urothelial Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.