Associated Genetic Biomarkers
Associated Diseases


Location [1]
Protein [2]
X-ray repair cross-complementing protein 5
Synonyms [1]
Ku86, KARP1, KUB2, NFIV, KARP-1, KU80

XRCC5 is altered in 0.98% of all cancers with colon adenocarcinoma, lung adenocarcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

XRCC5 GENIE Cases - Top Diseases

The most common alterations in XRCC5 are XRCC5 Mutation (0.15%), XRCC5 E287Kfs*11 (0.00%), XRCC5 E621K (0.00%), XRCC5 P446S (0.00%), and XRCC5 P711S (0.00%) [3].

XRCC5 GENIE Cases - Top Alterations

Significance of XRCC5 in Diseases

Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015.

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.