Location [1]
Protein [2]
X-ray repair cross-complementing protein 6
Synonyms [1]
CTC75, CTCBF, ML8, KU70, TLAA, G22P1

XRCC6 is altered in 1.12% of all cancers with colon adenocarcinoma, melanoma, endometrial endometrioid adenocarcinoma, lung adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence of alterations [3].

XRCC6 GENIE Cases - Top Diseases

The most common alterations in XRCC6 are XRCC6 Mutation (0.98%), XRCC6 T334A (0.07%), XRCC6 Amplification (0.06%), XRCC6 Fusion (0.03%), and XRCC6 G191S (0.03%) [3].

XRCC6 GENIE Cases - Top Alterations

Significance of XRCC6 in Diseases

Melanoma +

Urothelial Carcinoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.