Overview

Location [1]
18p11.32
Protein [2]
Tyrosine-protein kinase Yes
Synonyms [1]
Yes, c-yes, HsT441, P61-YES

YES proto-oncogene 1, Src family tyrosine kinase (YES1) is a gene that encodes a protein that functions as a tyrosine kinase. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and liver cancer.

YES1 is altered in 1.09% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, conventional glioblastoma multiforme, and cutaneous melanoma having the greatest prevalence of alterations [3].

YES1 GENIE Cases - Top Diseases

The most common alterations in YES1 are YES1 Amplification (0.34%), YES1 Mutation (0.29%), YES1 Loss (0.08%), YES1 S187* (0.01%), and YES1 R117I (0.01%) [3].

YES1 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.