Associated Genetic Biomarkers
YES proto-oncogene 1, Src family tyrosine kinase (YES1) is a gene that encodes a protein that functions as a tyrosine kinase. Missense mutations, nonsense mutations, silent mutations, and frameshift deletions are observed in cancers such as endometrial cancer, intestinal cancer, and liver cancer.
YES1 is altered in 1.25% of all cancers with lung adenocarcinoma, colon adenocarcinoma, breast invasive ductal carcinoma, endometrial endometrioid adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations .
The most common alterations in YES1 are YES1 Amplification (0.56%), YES1 Mutation (0.53%), YES1 Loss (0.13%), YES1 S187* (0.02%), and YES1 R117I (0.01%) .
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.