Overview

Location [1]
6q25.1
Protein [2]
Zinc finger and BTB domain-containing protein 2
Synonyms [1]
ZNF437

Zinc finger and BTB domain containing 2 (ZBTB2) is a gene that encodes a protein with unknown function. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as stomach cancer, colon cancer, and skin cancer.

ZBTB2 is altered in 1.00% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, cutaneous melanoma, lentigo maligna melanoma, and lung adenocarcinoma having the greatest prevalence of alterations [3].

ZBTB2 GENIE Cases - Top Diseases

The most common alterations in ZBTB2 are ZBTB2 Amplification (0.31%), ZBTB2 S289G (0.28%), ZBTB2 A185V (0.06%), ZBTB2 D422Y (0.09%), and ZBTB2 E19Q (0.06%) [3].

ZBTB2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.