Overview

Location [1]
13q12.11
Protein [2]
Zinc finger MYM-type protein 2
Synonyms [1]
FIM, ZNF198, SCLL, MYM, RAMP

Zinc finger, MYM-type 2 (ZMYM2) is a gene that encodes a protein that functions as a zinc finger transcription factor. The protein may also be a component of a BHC histone deactylase complex. Fusions, missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and stomach cancer.

ZMYM2 is altered in 0.34% of all cancers with breast invasive ductal carcinoma, high grade ovarian serous adenocarcinoma, colon adenocarcinoma, endometrial serous adenocarcinoma, and dysembryoplastic neuroepithelial tumor having the greatest prevalence of alterations [3].

ZMYM2 GENIE Cases - Top Diseases

The most common alterations in ZMYM2 are ZMYM2-FGFR1 Fusion (0.22%), ZMYM2 I314N (0.77%), ZMYM2 K336N (0.77%), ZMYM2 P299Q (0.77%), and ZMYM2 A39S (0.22%) [3].

ZMYM2 GENIE Cases - Top Alterations

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.