Location [1]
Protein [2]
Zinc finger MYM-type protein 3
Synonyms [1]
ZNF261, DXS6673E, ZNF198L2, MYM, XFIM

Zinc finger, MYM-type 3 (ZMYM3) is a gene that encodes a protein that functions as a component of histone-deacetylase-containing multiprotein complexes that silence genes through the modification of chromatin structure. Missense mutations, nonsense mutations, silent mutations, frameshift deletions and insertions, and in-frame deletions are observed in cancers such as endometrial cancer, intestinal cancer, and urinary tract cancer.

ZMYM3 is altered in 1.93% of all cancers with conventional glioblastoma multiforme, colon adenocarcinoma, pancreatic adenocarcinoma, basal cell carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence of alterations [3].

ZMYM3 GENIE Cases - Top Diseases

The most common alterations in ZMYM3 are ZMYM3 Mutation (1.59%), ZMYM3 T1157M (0.13%), ZMYM3 A1116S (0.07%), ZMYM3 A1328T (0.07%), and ZMYM3 A228V (0.09%) [3].

ZMYM3 GENIE Cases - Top Alterations

Significance of ZMYM3 in Diseases

Medulloblastoma +

Medulloblastoma, Non-WNT/Non-SHH +

Desmoplastic/Nodular Medulloblastoma +

Central Nervous System Embryonal Neoplasm +

Central Nervous System Ganglioneuroblastoma +

Central Nervous System Neuroblastoma +

Large Cell/Anaplastic Medulloblastoma +

Medulloblastoma With Extensive Nodularity +

Medulloblastoma, SHH-Activated +

Medulloblastoma, WNT-Activated +

Medulloepithelioma +

Glioblastoma +

Anaplastic Oligodendroglioma +

Malignant Glioma +

Anaplastic Astrocytoma +

Diffuse Glioma +

Anaplastic Astrocytoma, IDH-Mutant +

Anaplastic Ependymoma +

Anaplastic Oligodendroglioma, IDH-Mutant And 1p/19q-Codeleted +

Anaplastic Pleomorphic Xanthoastrocytoma +

Atypical Teratoid/Rhabdoid Tumor +

Diffuse Midline Glioma, H3 K27M-Mutant +

Embryonal Tumor With Multilayered Rosettes, C19MC-Altered +

Embryonal Tumor With Multilayered Rosettes, Not Otherwise Specified +

Ependymoma +

Ependymoma, RELA Fusion-Positive +

High-Grade Glioma, NOS +

Pineoblastoma +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.