Biomarkers /
ZNF703
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Associated Diseases
Overview
Zinc finger protein 703 (ZNF703) is a gene that encodes a protein that functions as a transcriptional corepressor that regulates transcription via histone deacetylases. Fusions, missense mutations, silent mutations, and frameshift insertions are observed in cancers such as liver cancer, stomach cancer, and thyroid cancer.
ZNF703 is altered in 3.64% of all cancers with breast invasive ductal carcinoma, colon adenocarcinoma, lung adenocarcinoma, pancreatic adenocarcinoma, and cutaneous melanoma having the greatest prevalence of alterations [3].
The most common alterations in ZNF703 are ZNF703 Amplification (3.10%), ZNF703 D403_P404insAPRRLQLLHLQRAD (2.87%), ZNF703 A401_H402insPTHLGGSSCSTCSA (2.48%), ZNF703 P422A (0.32%), and ZNF703 P13L (0.24%) [3].
References
1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta
2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.
3. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.
4. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.