Janus Kinase (JAK)/ Signal Transducers and Activators of Transcription (STAT) Signaling

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) cell signaling pathway functions as part of gene transcription and immune regulation. JAK1/2/3 are intracellular tyrosine kinases, whereas STAT1/2/3 are transcription factors that activate gene expression. The JAK/STAT pathway is activated by the binding of a ligand, such as interleukins, interferons, or growth factors, to specific cell surface receptors, which then convey signals downstream through the JAK/STAT pathway.

Figure 1. Receptor tyrosine kinases can promote activation of Janus kinases (JAK-1/-2/-3). Janus kinases auto-phosphorylate and recruit signal transducers and activators of transcription (STAT-1/-2/-3/-4/-5/-6). Phosphorylated STAT (-1/-2/-3/-4/-5/-6) proteins dimerize. The STAT (-1/-2/-3/-4/-5/-6) dimer enters the nucleus where it binds to DNA to activate gene transcription, regulate immunity, and promote cell growth and survival. Specific nodes in the pathway that are therapeutically actionable are noted. Click here to open a larger version of this image in a new window.

Upstream Pathways

Downstream Pathways

Cell cycle control

Diseases in Which Pathway is Aberrantly Activated

Therapies That Target This Pathway

JAK inhibitors

Genes Involved in the Pathway

Last Updated: May 24, 2016

Disclaimer: The information presented at MyCancerGenome.org is compiled from sources believed to be reliable. Extensive efforts have been made to make this information as accurate and as up-to-date as possible. However, the accuracy and completeness of this information cannot be guaranteed. Despite our best efforts, this information may contain typographical errors and omissions. The contents are to be used only as a guide, and health care providers should employ sound clinical judgment in interpreting this information for individual patient care.