Receptor Tyrosine Kinase/Growth Factor Signaling
Receptor tyrosine kinase cell signaling pathways regulate a variety of cellular processes including cell growth, proliferation, differentiation, survival, gene transcription, metabolic regulation, and others. Receptor tyrosine kinase signaling pathways are activated by the binding of a ligand, such as a growth factor, to the receptor tyrosine kinase. Receptor tyrosine kinase signaling pathways are inhibited by complex negative feedback loops which function to attenuate the activated receptor signaling.
Figure 1. Binding of a growth factor (e.g., EGF, HGF) to a receptor tyrosine kinase activates the receptor tyrosine kinase and typically causes the dimerization of the two receptor monomers. The receptors are activated by phosphorylation within their kinase domains. Once the receptor is turned on, numerous downstream pathways are activated including MAP kinase signaling, JAK/STAT signaling, and PI3K/AKT1/MTOR signaling. Specific nodes in the pathway that are therapeutically actionable are noted. Click here to open a larger version of this image in a new window.
Diseases in Which Pathway is Aberrantly Activated
- Acute myeloid leukemia
- Anaplastic large cell lymphoma
- Breast cancer
- Gastric cancer
- Lung cancer
- Thymic carcinoma
- Thyroid cancer
Therapies That Target This Pathway
Genes Involved in the Pathway
Last Updated: May 24, 2016