Kinase Fusions

Kinase fusion cell signaling pathways promote gene transcription, cell growth, proliferation, differentiation, and survival. These pathways also play a role in cellular metabolic regulation. Kinase fusions are abnormal genome alterations in tumor cells that result from the aberrant rearrangement of translocation of two genes, one of which encodes a protein kinase.

Figure 1. Kinase fusions activate downstream cell signaling pathways such as MAP kinase signaling, JAK/STAT signaling, and PI3K/AKT1/MTOR signaling. Ultimately, the activation of downstream cell signaling pathways promotes gene transcription, cell growth, proliferation, differentiation, and survival. Click here to open a larger version of this image in a new window.

Upstream Pathways

Receptor tyrosine kinase/growth factor signaling

Downstream Pathways

Diseases in Which Pathway is Aberrantly Activated

Therapies That Target This Pathway

Genes Involved in the Pathway

AKAP-BRAF
BCR-ABL1
Fusion gene-ALK
Fusion gene-FGFR1
Fusion gene-FGFR2
Fusion gene-FGFR3
Fusion gene-NTRK1
Fusion gene-NTRK2
Fusion gene-NTRK3
Fusion gene-RET
Fusion gene-ROS1

Last Updated: May 24, 2016

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