Overview

Gene Location [1]
2p23.2-p23.1
Pathways
Kinase fusions, Receptor tyrosine kinase/growth factor signaling
Variant Type
Amplification
Gene
ALK

ALK Amplification is present in 0.09% of AACR GENIE cases, with breast carcinoma, neuroblastoma, malignant glioma, non-small cell lung carcinoma, and prostate cancer having the greatest prevalence [4].

Top Disease Cases with ALK Amplification

Significance of ALK Amplification in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Cancer +

Anaplastic Large Cell Lymphoma +

Diffuse Large B-Cell Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Lymphoma +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

Neuroblastoma +

Adenocarcinoma Of The Gastroesophageal Junction +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

B-Cell Non-Hodgkin Lymphoma +

Burkitt Lymphoma +

Colorectal Carcinoma +

Double-Hit Lymphoma +

Gastric Carcinoma +

Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma +

Mediastinal Large B-Cell Lymphoma +

Non-Hodgkin Lymphoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Breast Carcinoma +

Glioblastoma +

Lung Carcinoma +

Melanoma +

ALK-Positive Large B-Cell Lymphoma +

Central Nervous System Neoplasm +

Cholangiocarcinoma +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

Esophageal Carcinoma +

Follicular Lymphoma +

Grade 3b Follicular Lymphoma +

Hepatocellular Carcinoma +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

Hodgkin Lymphoma +

Intravascular Large B-Cell Lymphoma +

Lymphoblastic Lymphoma +

Lymphomatoid Granulomatosis +

Malignant Neoplasm +

Mantle Cell Lymphoma +

Mature B-Cell Non-Hodgkin Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Multiple Myeloma +

Mycosis Fungoides +

Pancreatic Adenocarcinoma +

Pancreatic Carcinoma +

Primary Central Nervous System Lymphoma +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

Primary Effusion Lymphoma +

Sezary Syndrome +

Small Intestinal Carcinoma +

Transformed Lymphoma +

Triple-Hit Lymphoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20170629. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 4. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.