Gene Location [1]
Receptor tyrosine kinase/growth factor signaling, Kinase fusions
Variant Type

ALK Amplification is present in 0.10% of AACR GENIE cases, with breast invasive ductal carcinoma, neuroblastoma, breast invasive lobular carcinoma, prostate adenocarcinoma, and conventional glioblastoma multiforme having the greatest prevalence [4].

Top Disease Cases with ALK Amplification

Significance of ALK Amplification in Diseases

Non-Small Cell Lung Carcinoma +

Malignant Solid Tumor +

Diffuse Large B-Cell Lymphoma +

ALK-Positive Large B-Cell Lymphoma +

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

High Grade B-Cell Lymphoma, Not Otherwise Specified +

T-Cell/Histiocyte-Rich Large B-Cell Lymphoma +

Transformed Non-Hodgkin Lymphoma +

Cancer +

Anaplastic Large Cell Lymphoma +

B-Cell Lymphoma, Unclassifiable, With Features Intermediate Between Diffuse Large B-Cell Lymphoma And Classical Hodgkin Lymphoma +

Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation +

Double-Hit Lymphoma +

EBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Grade 3b Follicular Lymphoma +

Intravascular Large B-Cell Lymphoma +

Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type +

Neuroblastoma +

HHV8-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise Specified +

Mediastinal Large B-Cell Lymphoma +

Triple-Hit Lymphoma +

Melanoma +

B-Cell Non-Hodgkin Lymphoma +

Burkitt Lymphoma +

Follicular Lymphoma +

Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma +

High Grade B-Cell Lymphoma With MYC And BCL2 And/Or BCL6 Rearrangements +

Lymphoma +

Lymphomatoid Granulomatosis +

Mantle Cell Lymphoma +

Pancreatic Carcinoma +

Plasmablastic Lymphoma +

Primary Mediastinal B-Cell Lymphoma +

Thyroid Gland Undifferentiated (Anaplastic) Carcinoma +

Glioblastoma +

Central Nervous System Neoplasm +

Bladder Carcinoma +

Lung Carcinoma +

Adenocarcinoma Of The Gastroesophageal Junction +

Anaplastic Large Cell Lymphoma, ALK-Negative +

Anaplastic Large Cell Lymphoma, ALK-Positive +

Angioimmunoblastic T-Cell Lymphoma +

Atypical Burkitt/Burkitt-Like Lymphoma +

Biliary Tract Carcinoma +

Central Nervous System Lymphoma +

Cholangiocarcinoma +

Colorectal Carcinoma +

Diffuse Large B-Cell Lymphoma Activated B-Cell Type +

EBV-Positive Mucocutaneous Ulcer +

Enteropathy-Associated T-Cell Lymphoma +

Esophageal Carcinoma +

Extranodal Marginal Zone Lymphoma Of Mucosa-Associated Lymphoid Tissue +

Follicular T-Cell Lymphoma +

Gastric Carcinoma +

Hepatocellular Carcinoma +

Hepatosplenic T-Cell Lymphoma +

Hodgkin Lymphoma +

Indolent T-Cell Lymphoproliferative Disorder Of The Gastrointestinal Tract +

Large B-Cell Lymphoma With IRF4 Rearrangement +

Lymphoblastic Lymphoma +

Malignant Salivary Gland Neoplasm +

Mature B-Cell Non-Hodgkin Lymphoma +

Mature T-Cell And NK-Cell Non-Hodgkin Lymphoma +

Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma +

Mycosis Fungoides +

Nasal Type Extranodal NK/T-Cell Lymphoma +

Nodal Marginal Zone Lymphoma +

Nodal Peripheral T-Cell Lymphoma With TFH Phenotype +

Non-Hodgkin Lymphoma +

Pancreatic Adenocarcinoma +

Peripheral T-Cell Lymphoma, Not Otherwise Specified +

Primary Central Nervous System Lymphoma +

Primary Effusion Lymphoma +

Richter Syndrome +

Sezary Syndrome +

Small Intestinal Carcinoma +

Splenic Marginal Zone Lymphoma +

Subcutaneous Panniculitis-Like T-Cell Lymphoma +

Systemic EBV-Positive T-Cell Lymphoma Of Childhood +


1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.