Associated Genetic Biomarkers
ALK L1198F is present in 0.00% of AACR GENIE cases, with intrahepatic cholangiocarcinoma having the greatest prevalence .
ALK L1198F serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains ALK L1198F as an inclusion criterion, 1 is phase 2 (1 open).
Trials with ALK L1198F in the inclusion eligibility criteria most commonly target non-squamous non-small cell lung carcinoma .
Crizotinib is the most frequent therapy in trials with ALK L1198F as an inclusion criteria .
Significance of ALK L1198F in Diseases
Non-Squamous Non-Small Cell Lung Carcinoma +
ALK is altered in 5.43% of non-squamous non-small cell lung carcinoma patients .
ALK L1198F is an inclusion criterion in 1 clinical trial for non-squamous non-small cell lung carcinoma, of which 1 is open and 0 are closed. Of the trial that contains ALK L1198F and non-squamous non-small cell lung carcinoma as inclusion criteria, 1 is phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.