Associated Genetic Biomarkers
BRAF D594E is present in 0.01% of AACR GENIE cases.
BRAF D594E serves as an inclusion eligibility criterion in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains BRAF D594E as an inclusion criterion, 1 is phase 1 (0 open).
Trials with BRAF D594E in the inclusion eligibility criteria most commonly target malignant solid tumor and non-small cell lung carcinoma .
Cetuximab, pembrolizumab, bevacizumab, liver transplantation, and regorafenib are the most frequent therapies in trials with BRAF D594E as an inclusion criteria .
Significance of BRAF D594E in Diseases
Malignant Solid Tumor +
BRAF is mutated in 5.41% of malignant solid tumor patients with BRAF D594E present in 0.01% of all malignant solid tumor patients .
BRAF D594E is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 0 are open and 1 is closed. Of the trial that contains BRAF D594E and malignant solid tumor as inclusion criteria, 1 is phase 1 (0 open) .
Non-Small Cell Lung Carcinoma +
BRAF is mutated in 4.75% of non-small cell lung carcinoma patients .
BRAF D594E is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains BRAF D594E and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.