Associated Genetic Biomarkers
BRAF D594G is present in 0.13% of AACR GENIE cases, with colorectal adenocarcinoma, non-small cell lung carcinoma, melanoma, adenocarcinoma of unknown primary, and ovarian neoplasm having the greatest prevalence .
BRAF D594G serves as an inclusion eligibility criterion in 2 clinical trials, of which 1 is open and 1 is closed. Of the trials that contain BRAF D594G as an inclusion criterion, 2 are phase 1 (1 open).
Trials with BRAF D594G in the inclusion eligibility criteria most commonly target malignant solid tumor and non-small cell lung carcinoma .
Rmc-4630 is the most frequent therapy in trials with BRAF D594G as an inclusion criteria .
Significance of BRAF D594G in Diseases
Malignant Solid Tumor +
BRAF is mutated in 39.82% of malignant solid tumor patients with BRAF D594G present in 0.22% of all malignant solid tumor patients .
BRAF D594G is an inclusion criterion in 2 clinical trials for malignant solid tumor, of which 1 is open and 1 is closed. Of the trials that contain BRAF D594G and malignant solid tumor as inclusion criteria, 2 are phase 1 (1 open) .
Rmc-4630 is the most frequent therapy in trials for malignant solid tumor that contain BRAF D594G .
Non-Small Cell Lung Carcinoma +
BRAF is mutated in 5.34% of non-small cell lung carcinoma patients with BRAF D594G present in 0.16% of all non-small cell lung carcinoma patients .
BRAF D594G is an inclusion criterion in 1 clinical trial for non-small cell lung carcinoma, of which 0 are open and 1 is closed. Of the trial that contains BRAF D594G and non-small cell lung carcinoma as inclusion criteria, 1 is phase 1 (0 open) .
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