Associated Genetic Biomarkers
BRAF Deletion is present in 0.11% of AACR GENIE cases, with pancreatic adenocarcinoma, lung adenocarcinoma, cutaneous melanoma, prostate adenocarcinoma, and langerhans cell histiocytosis having the greatest prevalence .
BRAF Deletion serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains BRAF Deletion as an inclusion criterion, 1 is phase 2 (1 open).
Trials with BRAF Deletion in the inclusion eligibility criteria most commonly target malignant solid tumor and melanoma .
Binimetinib and encorafenib are the most frequent therapies in trials with BRAF Deletion as an inclusion criteria .
Significance of BRAF Deletion in Diseases
BRAF is altered in 35.7% of melanoma patients with BRAF Deletion present in 0.23% of all melanoma patients .
BRAF Deletion is an inclusion criterion in 1 clinical trial for melanoma, of which 1 is open and 0 are closed. Of the trial that contains BRAF Deletion and melanoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
BRAF is altered in 6.59% of malignant solid tumor patients with BRAF Deletion present in 0.09% of all malignant solid tumor patients .
BRAF Deletion is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains BRAF Deletion and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
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