Associated Genetic Biomarkers
BRAF G469A is present in 0.17% of AACR GENIE cases, with lung adenocarcinoma, prostate adenocarcinoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, colon adenocarcinoma, and bladder urothelial carcinoma having the greatest prevalence .
BRAF G469A serves as an inclusion eligibility criterion in 2 clinical trials, of which 2 are open and 0 are closed. Of the trials that contain BRAF G469A as an inclusion criterion, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open).
Trials with BRAF G469A in the inclusion eligibility criteria most commonly target non-small cell lung carcinoma, colorectal carcinoma, malignant solid tumor, melanoma, and colorectal adenocarcinoma .
Cetuximab, pembrolizumab, trastuzumab, cdx-3379, and folfiri regimen are the most frequent therapies in trials with BRAF G469A as an inclusion criteria .
Significance of BRAF G469A in Diseases
Malignant Solid Tumor +
BRAF is altered in 6.59% of malignant solid tumor patients with BRAF G469A present in 0.16% of all malignant solid tumor patients .
BRAF G469A is an inclusion criterion in 2 clinical trials for malignant solid tumor, of which 2 are open and 0 are closed. Of the trials that contain BRAF G469A and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open) .
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