Associated Genetic Biomarkers
BRAF N486_P490del is present in 0.02% of AACR GENIE cases, with pancreatic adenocarcinoma having the greatest prevalence .
BRAF N486_P490del serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains BRAF N486_P490del as an inclusion criterion, 1 is phase 1/phase 2 (1 open).
Trials with BRAF N486_P490del in the inclusion eligibility criteria most commonly target malignant solid tumor .
Binimetinib and encorafenib are the most frequent therapies in trials with BRAF N486_P490del as an inclusion criteria .
Significance of BRAF N486_P490del in Diseases
Malignant Solid Tumor +
BRAF is altered in 5.41% of malignant solid tumor patients with BRAF N486_P490del present in 0.02% of all malignant solid tumor patients .
BRAF N486_P490del is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains BRAF N486_P490del and malignant solid tumor as inclusion criteria, 1 is phase 1/phase 2 (1 open) .
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.