Associated Genetic Biomarkers
CCND1 Loss is present in 0.04% of AACR GENIE cases, with conventional glioblastoma multiforme, head and neck squamous cell carcinoma, adrenal cortex carcinoma, astrocytoma, and bladder urothelial carcinoma having the greatest prevalence .
CCND1 Loss serves as an inclusion eligibility criterion in 1 clinical trial, of which 1 is open and 0 are closed. Of the trial that contains CCND1 Loss as an inclusion criterion, 1 is phase 2 (1 open).
Trials with CCND1 Loss in the inclusion eligibility criteria most commonly target B-cell non-hodgkin lymphoma, malignant solid tumor, and multiple myeloma .
Palbociclib is the most frequent therapy in trials with CCND1 Loss as an inclusion criteria .
Significance of CCND1 Loss in Diseases
B-Cell Non-Hodgkin Lymphoma +
CCND1 is altered in 3.95% of B-cell non-hodgkin lymphoma patients with CCND1 Loss present in 0.09% of all B-cell non-hodgkin lymphoma patients .
CCND1 Loss is an inclusion criterion in 1 clinical trial for B-cell non-hodgkin lymphoma, of which 1 is open and 0 are closed. Of the trial that contains CCND1 Loss and B-cell non-hodgkin lymphoma as inclusion criteria, 1 is phase 2 (1 open) .
Malignant Solid Tumor +
CCND1 is altered in 4.48% of malignant solid tumor patients with CCND1 Loss present in 0.04% of all malignant solid tumor patients .
CCND1 Loss is an inclusion criterion in 1 clinical trial for malignant solid tumor, of which 1 is open and 0 are closed. Of the trial that contains CCND1 Loss and malignant solid tumor as inclusion criteria, 1 is phase 2 (1 open) .
Multiple Myeloma +
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4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.