Associated Genetic Biomarkers

Overview

NCI Definition: A bone marrow-based plasma cell neoplasm characterized by a serum monoclonal protein and skeletal destruction with osteolytic lesions, pathological fractures, bone pain, hypercalcemia, and anemia. Clinical variants include non-secretory myeloma, smoldering myeloma, indolent myeloma, and plasma cell leukemia. (WHO, 2001) [1]

Multiple myelomas most frequently harbor alterations in KRAS, TP53, NRAS, TET2, and DNMT3A [2].

Most Commonly Altered Genes in Multiple Myeloma

KRAS Mutation, TP53 Mutation, NRAS Mutation, TP53 c.217-c.1178 Missense, and TP53 Missense are the most common alterations in multiple myeloma [2].

Top Alterations in Multiple Myeloma

Significant Genes in Multiple Myeloma

ABL1 +

AFF1 +

AKT1 +

AKT2 +

AKT3 +

ALK +

ARAF +

ASXL1 +

ATM +

ATR +

BARD1 +

BCL2 +

BCL6 +

BCR +

BIRC3 +

BRAF +

BRCA1 +

BRCA2 +

BRIP1 +

CALR +

CBFB +

CCND1 +

CCND3 +

CDK12 +

CDK4 +

CDK6 +

CDKN2A +

CDKN2C +

CHEK1 +

CHEK2 +

CRKL +

CSF1R +

DEK +

DNMT3A +

EGFR +

ELL +

ERBB2 +

EZH2 +

FANCA +

FANCB +

FANCC +

FANCD2 +

FANCE +

FANCF +

FANCG +

FANCI +

FANCL +

FANCM +

FBXW7 +

FGF1 +

FGF10 +

FGF11 +

FGF12 +

FGF13 +

FGF14 +

FGF16 +

FGF17 +

FGF18 +

FGF19 +

FGF2 +

FGF20 +

FGF21 +

FGF22 +

FGF23 +

FGF3 +

FGF4 +

FGF5 +

FGF6 +

FGF7 +

FGF8 +

FGF9 +

FGFR1 +

FGFR2 +

FGFR3 +

FGFR4 +

FLCN +

FLT1 +

FLT3 +

FLT4 +

HRAS +

IDH1 +

IDH2 +

IGH +

IKZF1 +

JAK2 +

KDR +

KEAP1 +

KIT +

KMT2A +

KRAS +

MAF +

MAFB +

MAP2K1 +

MAP2K2 +

MAP2K4 +

MAP3K1 +

MAPK1 +

MCPH1 +

MDM2 +

MECOM +

MET +

MLF1 +

MLLT1 +

MLLT10 +

MLLT3 +

MLLT4 +

MPL +

MRE11A +

MTOR +

MYC +

MYH11 +

NBN +

NF1 +

NF2 +

NFE2L2 +

NFKB2 +

NPM1 +

NRAS +

NRIP3 +

NTRK1 +

NTRK2 +

NTRK3 +

NUP214 +

PALB2 +

PBX1 +

PDGFRA +

PDGFRB +

PHF6 +

PIK3CA +

PIK3R1 +

PML +

POLD1 +

POLE +

PTCH1 +

PTEN +

RAD50 +

RAD51 +

RAD51B +

RAD51C +

RAD51D +

RAD54L +

RAF1 +

RARA +

RET +

RHEB +

ROS1 +

RPN1 +

RUNX1 +

RUNX1T1 +

SF3B1 +

SLX4 +

SMO +

SRC +

SRSF2 +

STK11 +

TCF3 +

TET2 +

TP53 +

TSC1 +

TSC2 +

VHL +

WHSC1 +

Disease Details

Synonyms
myelomatosis, Myeloma, Kahler disease, MYELOMA, PLASMA CELL, MALIGNANT, Plasma Cell Myeloma, Myeloma, NOS, Bone marrow multiple myeloma
Parent(s)
Plasma Cell Neoplasm
Children
Refractory Plasma Cell Neoplasm, Osteosclerotic Plasma Cell Myeloma, Smoldering Plasma Cell Myeloma, Non-Secretory Plasma Cell Myeloma, Indolent Plasma Cell Myeloma, and Refractory Plasma Cell Myeloma
OncoTree Name
Plasma Cell Myeloma
OncoTree Code
PCM

References

1. National Cancer Institute. NCI Thesaurus Version 18.11d. https://ncit.nci.nih.gov/ncitbrowser/ [2018-08-28]. [2018-09-21].

2. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 8. This dataset does not represent the totality of the genetic landscape; see paper for more information.

3. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.