Overview

Gene Location [1]
12q14.1
Pathway
Cell cycle control
Variant Type
Amplification
Gene
CDK4

CDK4 Amplification is present in 1.65% of AACR GENIE cases, with lung adenocarcinoma, conventional glioblastoma multiforme, dedifferentiated liposarcoma, glioblastoma, and well differentiated liposarcoma having the greatest prevalence [4].

Top Disease Cases with CDK4 Amplification

Biomarker-Directed Therapies

Significance of CDK4 Amplification in Diseases

Liposarcoma +

Malignant Solid Tumor +

Malignant Glioma +

Breast Carcinoma +

Non-Small Cell Lung Carcinoma +

Melanoma +

Ovarian Carcinoma +

Acral Lentiginous Melanoma +

Glioblastoma +

Osteosarcoma +

Gallbladder Carcinoma +

Soft Tissue Sarcoma +

Lung Carcinoma +

Cancer +

Esophageal Carcinoma +

Pancreatic Carcinoma +

Bladder Carcinoma +

Squamous Cell Lung Carcinoma +

Malignant Uterine Neoplasm +

Ovarian Epithelial Tumor +

Adenocarcinoma Of The Gastroesophageal Junction +

Bile Duct Carcinoma +

Bronchogenic Carcinoma +

Cervical Carcinoma +

Chondrosarcoma +

Chordoma +

Colorectal Carcinoma +

Dedifferentiated Chondrosarcoma +

Endometrial Endometrioid Adenocarcinoma +

Esophageal Squamous Cell Carcinoma +

Fallopian Tube Carcinoma +

Gastric Adenocarcinoma +

Head And Neck Carcinoma +

Head And Neck Squamous Cell Carcinoma +

Lymphoma +

Meningioma +

Multiple Myeloma +

Primary Peritoneal Carcinoma +

References

1. Hart R and Prlic A. Universal Transcript Archive Repository. Version uta_20180821. San Francisco CA: Github;2015. https://github.com/biocommons/uta

2. The UniProt Consortium. UniProt: a worldwide hub of protein knowledge. Nucleic Acids Research. 2019;47:D506-D515.

3. Liu X, Wu C, Li C, and Boerwinkle E. dbNSFP v3.0: A one-stop database of functional predictions and annotations for human nonsynonymous and splice site SNVs. Human Mutation. 2015;37:235-241.

Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. Human Mutation. 2011;32:894-899.

4. The AACR Project GENIE Consortium. AACR Project GENIE: powering precision medicine through an international consortium. Cancer Discovery. 2017;7(8):818-831. Dataset Version 6. This dataset does not represent the totality of the genetic landscape; see paper for more information.

5. All assertions and clinical trial landscape data are curated from primary sources. You can read more about the curation process here.