Associated Genetic Biomarkers
CSF3R Mutation is present in 1.23% of AACR GENIE cases, with lung adenocarcinoma, colon adenocarcinoma, cutaneous melanoma, breast invasive ductal carcinoma, and endometrial endometrioid adenocarcinoma having the greatest prevalence .
CSF3R Mutation serves as an inclusion eligibility criterion in 1 clinical trial, of which 0 are open and 1 is closed. Of the trial that contains CSF3R Mutation as an inclusion criterion, 1 is phase 2 (0 open).
Trials with CSF3R Mutation in the inclusion eligibility criteria most commonly target atypical chronic myeloid leukemia, BCR-ABL1 negative and chronic neutrophilic leukemia .
Ruxolitinib is the most frequent therapy in trials with CSF3R Mutation as an inclusion criteria .
Significance of CSF3R Mutation in Diseases
Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative +
CSF3R Mutation is an inclusion criterion in 1 clinical trial for atypical chronic myeloid leukemia, BCR-ABL1 negative, of which 0 are open and 1 is closed. Of the trial that contains CSF3R Mutation and atypical chronic myeloid leukemia, BCR-ABL1 negative as inclusion criteria, 1 is phase 2 (0 open) .
Chronic Neutrophilic Leukemia +
CSF3R Mutation is an inclusion criterion in 1 clinical trial for chronic neutrophilic leukemia, of which 0 are open and 1 is closed. Of the trial that contains CSF3R Mutation and chronic neutrophilic leukemia as inclusion criteria, 1 is phase 2 (0 open) .
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